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Karl-Josef Langen Selected Research

Amino Acids

10/202118F-FET-PET-guided gross total resection improves overall survival in patients with WHO grade III/IV glioma: moving towards a multimodal imaging-guided resection.
1/2021Diagnosis of Pseudoprogression Following Lomustine-Temozolomide Chemoradiation in Newly Diagnosed Glioblastoma Patients Using FET-PET.
1/2021Current trends in the use of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in neurooncology.
12/2020Feature-based PET/MRI radiomics in patients with brain tumors.
11/2020Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression.
1/2020Advantages and limitations of amino acid PET for tracking therapy response in glioma patients.
1/2020Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors.
10/2019Treatment-Related Uptake of O-(2-18F-Fluoroethyl)-l-Tyrosine and l-[Methyl-3H]-Methionine After Tumor Resection in Rat Glioma Models.
4/2019Cis-4-[18F]fluoro-D-proline detects neurodegeneration in patients with akinetic-rigid parkinsonism.
1/2019Combined Amino Acid Positron Emission Tomography and Advanced Magnetic Resonance Imaging in Glioma Patients.
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Karl-Josef Langen Research Topics

Disease

69Glioma (Gliomas)
11/2022 - 08/2002
53Neoplasms (Cancer)
11/2022 - 07/2003
36Brain Neoplasms (Brain Tumor)
10/2021 - 08/2002
23Glioblastoma (Glioblastoma Multiforme)
12/2021 - 07/2012
11Alzheimer Disease (Alzheimer's Disease)
06/2021 - 09/2015
9Neoplasm Metastasis (Metastasis)
01/2021 - 09/2012
6Astrocytoma (Pilocytic Astrocytoma)
10/2021 - 01/2018
6Necrosis
01/2021 - 09/2012
5Radiation Injuries (Radiation Sickness)
01/2020 - 01/2017
4Stroke (Strokes)
01/2022 - 05/2015
4Spinal Cord Diseases
09/2013 - 12/2010
4Pathologic Constriction (Stenosis)
09/2013 - 12/2010
3Amyloidosis
06/2021 - 01/2019
3Residual Neoplasm
10/2019 - 01/2015
3Infarction (Infarctions)
06/2019 - 11/2006
3Brain Ischemia (Cerebral Ischemia)
01/2019 - 11/2006
3Meningioma (Meningiomas)
03/2015 - 11/2012
3Gliosis
08/2013 - 11/2006
3Abscess
06/2008 - 05/2006
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
04/2006 - 03/2005
2Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2022 - 06/2019
2Encephalitis (Encephalitis, Rasmussen)
01/2022 - 06/2019
2Brain Injuries (Brain Injury)
01/2022 - 06/2019
2Ischemic Stroke
01/2022 - 06/2019
2Cognitive Dysfunction
06/2021 - 01/2019
2Melanoma (Melanoma, Malignant)
01/2021 - 10/2016
2Lung Neoplasms (Lung Cancer)
01/2021 - 03/2005
2Medulloblastoma
01/2021 - 09/2016
2Status Epilepticus (Complex Partial Status Epilepticus)
10/2020 - 01/2017
2Seizures (Absence Seizure)
10/2020 - 01/2017
2Parkinsonian Disorders (Parkinsonism)
04/2019 - 10/2015
2Ischemia
01/2019 - 11/2006
2Prostatic Neoplasms (Prostate Cancer)
02/2018 - 03/2005
2Nervous System Diseases (Neurological Disorders)
10/2015 - 05/2015
2Head and Neck Neoplasms (Head and Neck Cancer)
02/2006 - 03/2005
1Amyloid Plaque
06/2021
1Epilepsy (Aura)
10/2020
1Gliosarcoma
07/2020

Drug/Important Bio-Agent (IBA)

48Tyrosine (L-Tyrosine)FDA Link
12/2021 - 07/2003
41Amino AcidsFDA Link
10/2021 - 11/2006
12Temozolomide (Temodar)FDA LinkGeneric
11/2022 - 07/2012
10Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
11/2022 - 01/2018
6Proteins (Proteins, Gene)FDA Link
11/2022 - 08/2002
6Biological ProductsIBA
01/2022 - 09/2016
6Amyloid (Amyloid Fibrils)IBA
06/2021 - 09/2015
6Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
01/2017 - 03/2005
5(18F)fluoroethyltyrosineIBA
01/2020 - 05/2006
5Proline (L-Proline)FDA Link
04/2019 - 11/2008
5Bevacizumab (Avastin)FDA Link
12/2018 - 01/2013
5Peptides (Polypeptides)IBA
03/2018 - 01/2014
5thiamine triphosphorate (TTP)IBA
01/2018 - 12/2013
4Methionine (L-Methionine)FDA Link
10/2019 - 07/2003
3LigandsIBA
10/2021 - 11/2012
3Pharmaceutical PreparationsIBA
10/2021 - 11/2016
3Dihydroxyphenylalanine (Dopa)IBA
01/2021 - 05/2015
3Lomustine (CCNU)FDA Link
01/2021 - 07/2012
3Dexamethasone (Maxidex)FDA LinkGeneric
05/2020 - 06/2016
3Glucose (Dextrose)FDA LinkGeneric
09/2013 - 12/2010
2Somatostatin Receptors (Somatostatin Receptor)IBA
11/2022 - 11/2012
2ArgonIBA
01/2022 - 06/2019
2Neuroprotective AgentsIBA
01/2022 - 06/2019
2fluorodopa F 18IBA
01/2022 - 09/2016
2Immune Checkpoint InhibitorsIBA
01/2021 - 11/2020
2Biomarkers (Surrogate Marker)IBA
12/2020 - 01/2019
2SodiumIBA
10/2020 - 01/2020
2EnzymesIBA
10/2020 - 01/2020
2salicylhydroxamic acid (SHAM)IBA
10/2019 - 06/2019
2OsteopontinIBA
01/2019 - 01/2017
2Phenylalanine (L-Phenylalanine)FDA Link
01/2017 - 01/2015
2Amyloid beta-PeptidesIBA
11/2016 - 08/2016
2Dopamine (Intropin)FDA LinkGeneric
10/2015 - 10/2012
2AcidsIBA
04/2013 - 04/2011
2GadoliniumIBA
07/2012 - 11/2004
1AntigensIBA
12/2021
1Heparin-binding EGF-like Growth Factor (HB-EGF)IBA
10/2021
1polyethylene glycol polyethyleneimine nanogelIBA
10/2021
1NanogelsIBA
10/2021
1DeoxyuridineIBA
10/2021
1DNA (Deoxyribonucleic Acid)IBA
10/2021
1Peptide Hydrolases (Proteases)FDA Link
10/2021
1ThymidineIBA
10/2021
1RadiopharmaceuticalsIBA
10/2021
1Matrix Metalloproteinases (MMPs)IBA
10/2021
1Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA
06/2021
14- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA
01/2021
1MethyltransferasesIBA
01/2021
1Kainic Acid (Kainate)IBA
10/2020
1Pentylenetetrazole (Metrazol)IBA
10/2020
1Hydrogenase (Ferredoxin Hydrogenase)IBA
07/2020
1isocitric acid (isocitrate)IBA
07/2020
1gallium 68 PSMA-11IBA
05/2020
1N,N'- bis(2- hydroxy- 5- (ethylene- beta- carboxy)benzyl)ethylenediamine N,N'-diacetic acidIBA
05/2020
1Hypnotics and Sedatives (Sedatives)IBA
01/2020

Therapy/Procedure

26Therapeutics
11/2022 - 08/2002
18Radiotherapy
05/2021 - 01/2007
7Drug Therapy (Chemotherapy)
11/2022 - 01/2015
7Chemoradiotherapy
11/2018 - 07/2012
5Immunotherapy
12/2021 - 01/2017
3Aftercare (After-Treatment)
12/2018 - 07/2012
2Combined Modality Therapy
01/2020 - 12/2018